A SUMO-regulated activation function controls synergy of c-Myb through a repressor–activator switch leading to differential p300 recruitment

Synergy between transcription factors operating together on complex promoters is a key aspect of gene activation. The ability of specific factors to synergize is restricted by sumoylation (synergy control, SC). Focusing on the haematopoietic transcription factor c-Myb, we found evidence for a strong...

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Detalhes bibliográficos
Main Authors: Molværsmyr, Ann-Kristin, Sæther, Thomas, Gilfillan, Siv, Lorenzo, Petra Isabel, Kvaløy, Heidi, Matre, Vilborg, Gabrielsen, Odd Stokke
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926607/
https://ncbi.nlm.nih.gov/pubmed/20385574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq245
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