Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

XRCC1 operates as a scaffold protein in base excision repair, a pathway that copes with base and sugar damage in DNA. Studies using recombinant XRCC1 proteins revealed that: a C389Y substitution, responsible for the repair defects of the EM-C11 CHO cell line, caused protein instability; a V86R mutat...

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Bibliografiske detaljer
Main Authors: Berquist, Brian R., Singh, Dharmendra Kumar, Fan, Jinshui, Kim, Daemyung, Gillenwater, Elizabeth, Kulkarni, Avanti, Bohr, Vilhelm A., Ackerman, Eric J., Tomkinson, Alan E., Wilson, David M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926592/
https://ncbi.nlm.nih.gov/pubmed/20385586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq193
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