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Genetic Dissection of Dietary Restriction in Mice Supports the Metabolic Efficiency Model of Life Extension

Dietary restriction (DR) has been used for decades to retard aging in rodents, but its mechanism of action remains an enigma. A principal roadblock has been that DR affects many different processes, making it difficult to distinguish cause and effect. To address this problem, we applied a quantitati...

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Bibliographic Details
Main Authors: Rikke, Brad A., Liao, Chen-Yu, McQueen, Matthew B., Nelson, James F., Johnson, Thomas E.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926251/
https://ncbi.nlm.nih.gov/pubmed/20452416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2010.04.008
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