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Anilinic N-Oxides Support Cytochrome P450-Mediated N-Dealkylation through Hydrogen-Atom Transfer

The mechanism of N-dealkylation mediated by cytochrome P450 (P450) has long been studied and argued as either a single electron transfer (SET) or a hydrogen atom transfer (HAT) from the amine to the oxidant of the P450, the reputed iron–oxene. In our study, tertiary anilinic N-oxides were used as ox...

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Detalhes bibliográficos
Main Authors: Roberts, Kenneth M., Jones, Jeffery P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925637/
https://ncbi.nlm.nih.gov/pubmed/20521282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201000185
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