Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions

We showed that XPC complex, which is a DNA damage detector for nucleotide excision repair, stimulates activity of thymine DNA glycosylase (TDG) that initiates base excision repair. XPC appeared to facilitate the enzymatic turnover of TDG by promoting displacement from its own product abasic site, al...

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Detalhes bibliográficos
Main Authors: Shimizu, Yuichiro, Uchimura, Yasuhiro, Dohmae, Naoshi, Saitoh, Hisato, Hanaoka, Fumio, Sugasawa, Kaoru
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925305/
https://ncbi.nlm.nih.gov/pubmed/20798892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/805698
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