Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter gene expression globally and thus affect memory processes in a nonspecific manner. Here, we show that the en...

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Auteurs principaux: Vecsey, Christopher G., Hawk, Joshua D., Lattal, K. Matthew, Stein, Joel M., Fabian, Sara A., Attner, Michelle A., Cabrera, Sara M., McDonough, Conor B., Brindle, Paul K., Abel, Ted, Wood, Marcelo A.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2007
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925045/
https://ncbi.nlm.nih.gov/pubmed/17553985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0296-07.2007
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