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Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation

BACKGROUND: Proteins involved in the DNA damage response accumulate as microscopically-visible nuclear foci on the chromatin flanking DNA double-strand breaks (DSBs). As growth of ionizing radiation (IR)-induced foci amplifies the ATM-dependent DNA damage signal, the formation of discrete foci plays...

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Detalhes bibliográficos
Main Authors: Ishikawa, Aya, Yamauchi, Motohiro, Suzuki, Keiji, Yamashita, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924841/
https://ncbi.nlm.nih.gov/pubmed/20684759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2041-9414-1-10
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