Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death

X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase apoptotic activity. XIAP also functions as an E3 ubiquitin ligase, targeting caspases for degradation. However, molecular pathways controlling XIAP activities remain unclear. Here we report that nitric oxide (NO) reacts with XI...

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Detalhes bibliográficos
Main Authors: Nakamura, Tomohiro, Wang, Lei, Wong, Catherine C. L., Scott, Fiona L., Eckelman, Brendan P., Han, Xuemei, Tzitzilonis, Christos, Meng, Fanjun, Gu, Zezong, Holland, Emily A., Clemente, Arjay T., Okamoto, Shu-ichi, Salvesen, Guy S., Riek, Roland, Yates, John R., Lipton, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924818/
https://ncbi.nlm.nih.gov/pubmed/20670888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.002
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