Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF

The TNFα converting enzyme (TACE/ADAM17) is involved in the proteolytic release of the ectodomain of diverse cell surface proteins with critical roles in development, immunity and hematopoiesis. As the perinatal lethality of TACE-deficient mice has prevented an analysis of the roles of TACE in adult...

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Main Authors: Horiuchi, Keisuke, Kimura, Tokuhiro, Miyamoto, Takeshi, Miyamoto, Kana, Akiyama, Haruhiko, Takaishi, Hironari, Morioka, Hideo, Nakamura, Takashi, Okada, Yasunori, Blobel, Carl P., Toyama, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924677/
https://ncbi.nlm.nih.gov/pubmed/19201862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802491
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