Non-Peptide Macrocyclic Histone Deacetylase Inhibitors Derived from Tricyclic Ketolide Skeleton

Inhibition of histone deacetylase (HDAC) function is a validated therapeutic strategy for cancer treatment. Of the several structurally distinct small molecule histone deacetylase inhibitors (HDACi) reported, macrocyclic depsipeptides possess the most complex cap-groups and have demonstrated excelle...

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Main Authors: Mwakwari, Sandra C., Guerrant, William, Patil, Vishal, Khan, Shabana I., Tekwani, Babu L., Gurard-Levin, Zachary A., Mrksich, Milan, Oyelere, Adegboyega K.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924451/
https://ncbi.nlm.nih.gov/pubmed/20669972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100507q
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