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Functional Characterisation and Drug Target Validation of a Mitotic Kinesin-13 in Trypanosoma brucei

Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies. Phylogenetic analyses have assigned five of the a...

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Detaylı Bibliyografya
Asıl Yazarlar: Chan, Kuan Yoow, Matthews, Keith R., Ersfeld, Klaus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924347/
https://ncbi.nlm.nih.gov/pubmed/20808899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001050
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