Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

Dysregulated Janus kinase–signal transducer and activator of transcription (JAK-STAT) signaling due to activation of tyrosine kinases is a common feature of myeloid malignancies. Here we report the first human disease-related mutations in the adaptor protein LNK, a negative regulator of JAK-STAT sig...

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Главные авторы: Oh, Stephen T., Simonds, Erin F., Jones, Carol, Hale, Matthew B., Goltsev, Yury, Gibbs, Kenneth D., Merker, Jason D., Zehnder, James L., Nolan, Garry P., Gotlib, Jason
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924231/
https://ncbi.nlm.nih.gov/pubmed/20404132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270108
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