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Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine

6-n-propylthiouracil (PTU) administered to male Sprague-Dawley rats maintained on 2 and 5 μg L-thyroxine (T(4))/100 g body weight resulted in a marked reduction in the rate of conversion of L-thyroxine to L-triiodothyronine (T(3)). These effects could not be ascribed to induced hypothyroidism since...

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Udgivet i:J Clin Invest
Principais autores: Oppenheimer, Jack H., Schwartz, Harold L., Surks, Martin I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1972
Fag:
Concise Publications
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292418/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4639029/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107063
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