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Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine: An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone

6-n-propylthiouracil (PTU) administered to male Sprague-Dawley rats maintained on 2 and 5 μg L-thyroxine (T(4))/100 g body weight resulted in a marked reduction in the rate of conversion of L-thyroxine to L-triiodothyronine (T(3)). These effects could not be ascribed to induced hypothyroidism since...

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Hlavní autoři: Oppenheimer, Jack H., Schwartz, Harold L., Surks, Martin I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1972
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC292418/
https://ncbi.nlm.nih.gov/pubmed/4639029
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