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Energetics of Calmodulin Domain Interactions with the Calmodulin Binding Domain of CaMKII
Calmodulin (CaM) is an essential eukaryotic calcium receptor that regulates many kinases, including CaMKII. Calcium-depleted CaM does not bind to CaMKII under physiological conditions. However, binding of (Ca(2+))(4)-CaM to a basic amphipathic helix in CaMKII releases auto-inhibition of the kinase....
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924166/ https://ncbi.nlm.nih.gov/pubmed/19089983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22317 |
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