RHAMM Promotes Interphase Microtubule Instability and Mitotic Spindle Integrity through MEK1/ERK1/2 Activity

An oncogenic form of RHAMM (receptor for hyaluronan-mediated motility, mouse, amino acids 163–794 termed RHAMM(Δ163)) is a cell surface hyaluronan receptor and mitotic spindle protein that is highly expressed in aggressive human cancers. Its regulation of mitotic spindle integrity is thought to cont...

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Main Authors: Tolg, Cornelia, Hamilton, Sara R., Morningstar, Lyndsey, Zhang, Jing, Zhang, S., Esguerra, Kenneth V., Telmer, Patrick G., Luyt, Len G., Harrison, Rene, McCarthy, James B., Turley, Eva A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924079/
https://ncbi.nlm.nih.gov/pubmed/20558733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121491
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