Identification, Design and Synthesis of Tubulin-Derived Peptides as Novel Hyaluronan Mimetic Ligands for the Receptor for Hyaluronan-Mediated Motility (RHAMM/HMMR)

Fragments of the extracellular matrix component hyaluronan (HA) promote tissue inflammation, fibrosis and tumor progression. HA fragments act through HA receptors including CD44, LYVE1, TLR2,4 and the receptor for hyaluronan mediated motility (RHAMM/HMMR). RHAMM is a multifunctional protein with bot...

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Publicado en:Integr Biol (Camb)
Main Authors: Esguerra, Kenneth V. N., Tolg, Cornelia, Akentieva, Natalia, Price, Matthew, Cho, Choi-Fong, Lewis, John D., McCarthy, James B., Turley, Eva A., Luyt, Leonard G.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721638/
https://ncbi.nlm.nih.gov/pubmed/26456171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ib00222b
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