Involvement of Grb2 Adaptor Protein in Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK)-mediated Signaling and Anaplastic Large Cell Lymphoma Growth

Most anaplastic large cell lymphomas (ALCL) express oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. Frequently ALCL carry the t(2;5) translocation, which fuses the ALK gene to the nucleophosmin (NPM1) gene. The transformin...

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Hlavní autoři: Riera, Ludovica, Lasorsa, Elena, Ambrogio, Chiara, Surrenti, Nadia, Voena, Claudia, Chiarle, Roberto
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924075/
https://ncbi.nlm.nih.gov/pubmed/20554525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116327
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