Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

MAPK phosphatase-1 (DUSP1/MKP-1) is a mitogen and stress-inducible dual specificity protein phosphatase, which can inactivate all three major classes of MAPK in mammalian cells. DUSP1/MKP-1 is implicated in cellular protection against a variety of genotoxic insults including hydrogen peroxide, ioniz...

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Detalhes bibliográficos
Main Authors: Staples, Christopher J., Owens, David M., Maier, Jana V., Cato, Andrew C. B., Keyse, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923983/
https://ncbi.nlm.nih.gov/pubmed/20547488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.117911
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