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Phosphorylation and Ubiquitination of Degron Proximal Residues Are Essential for Class II Transactivator (CIITA) Transactivation and Major Histocompatibility Class II Expression

Major histocompatibility (MHC) class II molecules are cell surface glycoproteins that present extracellular antigens to CD4(+) T cells and are essential for initiation of the adaptive immune response. MHC class II expression requires recruitment of a master regulator, the class II transactivator (CI...

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Main Authors: Bhat, Kavita Purnanda, Truax, Agnieszka Dorota, Greer, Susanna Fletcher
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923977/
https://ncbi.nlm.nih.gov/pubmed/20538595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127746
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