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Insulin-Like Growth Factor Regulates Peak Bone Mineral Density in Mice by Both Growth Hormone-Dependent and -Independent Mechanisms

To evaluate the relative contribution of the GH/IGF axis to the development of peak bone mineral density (BMD), we measured skeletal changes in IGF-I knockout (KO), IGF-II KO, and GH-deficient lit/lit mice and their corresponding control mice at d 23 (prepubertal), 31 (pubertal), and 56 (postpuberta...

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Bibliografische gegevens
Hoofdauteurs: Mohan, Subburaman, Richman, Charmaine, Guo, Rongqing, Amaar, Yousef, Donahue, Leah Rea, Wergedal, Jon, Baylink, David J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2003
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923925/
https://ncbi.nlm.nih.gov/pubmed/12586770
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