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Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac purkinje fibers

Lidocaine depresses automaticity in cardiac Purkinje fibers by decreasing the slope of slow diastolic depolarization, but the mechanisms of this effect are poorly understood. To test the proposal that the antiautomatic effect of lidocaine might be mediated by an increase in membrane potassium conduc...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Arnsdorf, Morton F., Bigger, J. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1972
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292389/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4639011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107034
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