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Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac purkinje fibers

Lidocaine depresses automaticity in cardiac Purkinje fibers by decreasing the slope of slow diastolic depolarization, but the mechanisms of this effect are poorly understood. To test the proposal that the antiautomatic effect of lidocaine might be mediated by an increase in membrane potassium conduc...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Arnsdorf, Morton F., Bigger, J. Thomas
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1972
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292389/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4639011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107034
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