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The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathologic...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923840/ https://ncbi.nlm.nih.gov/pubmed/20603072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.06.017 |
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