The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity

Anti-HER2/neu antibody therapy is reported to mediate tumor regression by interrupting oncogenic signals and/or inducing FcR-mediated cytotoxicity. Here, we demonstrate that the mechanisms of tumor regression by this therapy also require the adaptive immune response. Activation of innate immunity an...

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Hlavní autoři: Park, SaeGwang, Jiang, Zhujun, Mortenson, Eric D., Deng, Liufu, Radkevich-Brown, Olga, Yang, Xuanming, Sattar, Husain, Wang, Yang, Brown, Nicholas K., Greene, Mark, Liu, Yang, Tang, Jie, Wang, Shengdian, Fu, Yang-Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923645/
https://ncbi.nlm.nih.gov/pubmed/20708157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.06.014
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