Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho affects phosphate homeostasis is unknown. We detected Klotho in the proximal tubule cell, brush border, and urinary lumen, where phosphate homeostasis resides. Increasing Klotho in the kidney and urine chronically...

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Autori principali: Hu, Ming Chang, Shi, Mingjun, Zhang, Jianning, Pastor, Johanne, Nakatani, Teruyo, Lanske, Beate, Razzaque, M. Shawkat, Rosenblatt, Kevin P., Baum, Michel G., Kuro-o, Makoto, Moe, Orson W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2010
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Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923354/
https://ncbi.nlm.nih.gov/pubmed/20466874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-154765
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