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Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry

The heterocyclic aromatic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed by the grilled cooking of certain foods such as meats, poultry and fish. PhIP has been shown to induce tumours in the colon, prostate and mammary glands of rats and is regarded as a potential human diet...

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Autors principals: Singh, Rajinder, Arlt, Volker M., Henderson, Colin J., Phillips, David H., Farmer, Peter B., da Costa, Gonçalo Gamboa
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923026/
https://ncbi.nlm.nih.gov/pubmed/20598652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2010.06.008
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