Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA

The carcinogenic heterocyclic amine (HA) 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed during the cooking of various meats. To enable structure/activity studies aimed at understanding how DNA damaged by a member of the HA class of compounds can ultimately lead to cancer, we have d...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Brown, Karen, Hingerty, Brian E., Guenther, Elizabeth A., Krishnan, V. V., Broyde, Suse, Turteltaub, Kenneth W., Cosman, Monique
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37466/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438709/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.151251898
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