Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models

We describe the pharmacological and pharmacokinetic profiles of SCH 486757, a nociceptin/orphanin FQ peptide (NOP) receptor agonist that has recently entered human clinical trials for cough. SCH 486757 selectively binds human NOP receptor (K(i) = 4.6 ± 0.61 nM) over classical opioid receptors. In a...

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מידע ביבליוגרפי
Main Authors: McLeod, Robbie L., Tulshian, Deen B., Bolser, Donald C., Varty, Geoffrey B., Baptista, Marco, Fernandez, Xiomara, Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Ho, Ginny D., Jia, Yanlin, Ng, Fay W., Korfmacher, Walter, Xu, Xiaoying, Veals, John, Smith-Torhan, April, Wainhaus, Samuel, Fawzi, Ahmad B., Austin, Theodore M., van Heek, Margaret, Hey, John A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922759/
https://ncbi.nlm.nih.gov/pubmed/20006596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.12.003
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