Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma

Kaposi's sarcoma (KS) is an enigmatic vascular tumor thought to be a consequence of dysregulated expression of the human herpesvirus-8 (HHV-8 or KSHV)-encoded G protein-coupled receptor (vGPCR). Indeed, transgenic animals expressing vGPCR manifest vascular tumors histologically identical to hum...

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Detalhes bibliográficos
Main Authors: Ma, Tao, Jham, Bruno C., Hu, Jiadi, Friedman, Eitan R., Basile, John R., Molinolo, Alfredo, Sodhi, Akrit, Montaner, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922606/
https://ncbi.nlm.nih.gov/pubmed/20660728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001065107
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