Redox sensor SsrB Cys(203) enhances Salmonella fitness against nitric oxide generated in the host immune response to oral infection

We show herein that the Salmonella pathogenicity island 2 (SPI2) response regulator SsrB undergoes S-nitrosylation upon exposure of Salmonella to acidified nitrite, a signal encountered by this enteropathogen in phagosomes of macrophages. Mutational analysis has identified Cys(203) in the C-terminal...

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Detalles Bibliográficos
Autores principales: Husain, Maroof, Jones-Carson, Jessica, Song, Miryoung, McCollister, Bruce D., Bourret, Travis J., Vázquez-Torres, Andrés
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922535/
https://ncbi.nlm.nih.gov/pubmed/20660761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005299107
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