Constitutively active NF-κB triggers systemic TNFα-dependent inflammation and localized TNFα-independent inflammatory disease

NF-κB is well established as a key component of the inflammatory response. However, the precise mechanisms through which NF-κB activation contributes to inflammatory disease states remain poorly defined. To test the role of NF-κB in inflammation, we created a knock-in mouse that expresses a constitu...

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Bibliographic Details
Main Authors: Dong, Jie, Jimi, Eijiro, Zeiss, Caroline, Hayden, Matthew S., Ghosh, Sankar
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922500/
https://ncbi.nlm.nih.gov/pubmed/20713516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1958410
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