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Repression of gene expression by unphosphorylated NF-κB p65 through epigenetic mechanisms
Cells from a “knock-in” mouse expressing a NF-κB p65 mutant bearing an alanine instead of serine at position 276 (S276A) display a significant reduction of NF-κB-dependent transcription, even though the mutant p65 forms appropriate complexes that translocate normally to the nucleus and bind to DNA....
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| Asıl Yazarlar: | , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2335313/ https://ncbi.nlm.nih.gov/pubmed/18408078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1657408 |
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