Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells

INTRODUCTION: Normal and malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew, referred to as stem cells, or tumor initiating cells (TIC). These cells can be enriched by growth as “mammospheres” in three-dimensional cultures. OBJECTIVE: We tested t...

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Main Authors: Klopp, Ann H., Lacerda, Lara, Gupta, Anshul, Debeb, Bisrat G., Solley, Travis, Li, Li, Spaeth, Erika, Xu, Wei, Zhang, Xiaomei, Lewis, Michael T., Reuben, James M., Krishnamurthy, Savitri, Ferrari, Mauro, Gaspar, Rogério, Buchholz, Thomas A., Cristofanilli, Massimo, Marini, Frank, Andreeff, Michael, Woodward, Wendy A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922340/
https://ncbi.nlm.nih.gov/pubmed/20808935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012180
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