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The inhibition by methylmalonic acid of malate transport by the dicarboxylate carrier in rat liver mitochondria: A possible explanation for hypoglycemia in methylmalonic aciduria

We report the effects of methylmalonic acid (MMA) on the mitochondrial transport systems for malate, α-oxoglutarate, and isocitrate. MMA is shown to be a substrate for all three carrier systems, and an inhibitor of the malate-phosphate exchange carrier. The effects of MMA on the metabolism of malate...

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Autori principali: Halperin, M. L., Schiller, C. M., Fritz, I. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1971
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC292169/
https://ncbi.nlm.nih.gov/pubmed/4398537
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