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The inhibition by methylmalonic acid of malate transport by the dicarboxylate carrier in rat liver mitochondria: A possible explanation for hypoglycemia in methylmalonic aciduria
We report the effects of methylmalonic acid (MMA) on the mitochondrial transport systems for malate, α-oxoglutarate, and isocitrate. MMA is shown to be a substrate for all three carrier systems, and an inhibitor of the malate-phosphate exchange carrier. The effects of MMA on the metabolism of malate...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1971
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC292169/ https://ncbi.nlm.nih.gov/pubmed/4398537 |
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