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SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model

Cervical cancer is the leading cause of cancer-related deaths among women worldwide. Current prophylactic vaccines based on HPV (Human papillomavirus) late gene protein, L1 are ineffective in therapeutic settings. Therefore, there is an acute need for the development of therapeutic vaccines for HPV...

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Главные авторы: Sharma, Rajesh K., Srivastava, Abhishek K., Yolcu, Esma S., MacLeod, Kathryn J., Schabowsky, Rich-Henry, Madireddi, Shravan, Shirwan, Haval
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921468/
https://ncbi.nlm.nih.gov/pubmed/20603135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.06.073
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