Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells

SAG (Sensitive to Apoptosis Gene) (also known as RBX2 or ROC2) is a dual function protein with antioxidant activity while acting alone or E3 ligase activity when complexed with other components of SCF (Skp1-cullins-F box proteins) E3 ubiquitin ligases. SAG acts as a survival protein to inhibit apopt...

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Main Authors: Tan, Mingjia, Zhu, Yueming, Kovacev, Jordan, Zhao, Yongchao, Pan, Zhen-Qiang, Spitz, Douglas R., Sun, Yi
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921456/
https://ncbi.nlm.nih.gov/pubmed/20638939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.05.030
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