Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase in spinal cord injures rats

PURPOSE: We investigated whether replication-defective herpes simplex virus (HSV) vectors encoding genes of glutamic acid decarboxylase (GAD), the gamma-aminobutyric acid synthesis enzyme, can suppress detrusor-sphincter dyssynergia (DSD) in rats with spinal cord injury (SCI). MATERIALS AND METHODS:...

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Autors principals: Miyazato, Minoru, Sugaya, Kimio, Saito, Seiichi, Chancellor, Michael B., Goins, William F., Goss, James R., de Groat, William C., Glorioso, Joseph C., Yoshimura, Naoki
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921014/
https://ncbi.nlm.nih.gov/pubmed/20663524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2010.04.066
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