Fra-2 mediates oxygen-sensitive induction of transforming growth factor β in cardiac fibroblasts

AIMS: In the ischaemia-reperfused heart, transforming growth factor β (TGFβ) proteins trigger the differentiation of cardiac fibroblasts (CFs) contributing to fibrosis. Reoxygenation of the heart, in addition to being a trigger for reperfusion injury, induces tissue remodelling by hyperoxia-sensitiv...

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Autores principales: Roy, Sashwati, Khanna, Savita, Azad, Ali, Schnitt, Rebecca, He, Guanglong, Weigert, Cora, Ichijo, Hidenori, Sen, Chandan K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920807/
https://ncbi.nlm.nih.gov/pubmed/20427335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq123
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