Autophagy termination and lysosome reformation regulated by mTOR

Autophagy is an evolutionarily conserved process to catabolize cytoplasmic proteins and organelles1, 2. During starvation, the target of rapamycin (TOR), a nutrient-responsive kinase, is inhibited, thereby inducing autophagy. In autophagy, double-membrane autophagosomes envelop and sequester intrace...

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Hauptverfasser: Yu, Li, McPhee, Christina K., Zheng, Lixin, Mardones, Gonzalo A., Rong, Yueguang, Peng, Junya, Mi, Na, Zhao, Ying, Liu, Zhihua, Wan, Fengyi, Hailey, Dale W., Oorschot, Viola, Klumperman, Judith, Baehrecke, Eric H., Lenardo, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920749/
https://ncbi.nlm.nih.gov/pubmed/20526321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09076
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