Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

In response to G2 DNA damage, the p53 pathway is activated to lead to cell-cycle arrest, but how p53 is eliminated during the subsequent recovery process is poorly understood. It has been established that Polo-like kinase 1 (Plk1) controls G2 DNA-damage recovery. However, whether Plk1 activity contr...

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Bibliographic Details
Main Authors: Liu, X Shawn, Li, Hongchang, Song, Bing, Liu, Xiaoqi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920445/
https://ncbi.nlm.nih.gov/pubmed/20577264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.90
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