The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons

BACKGROUND: A major pathological hallmark of AD is the deposition of insoluble extracellular β-amyloid (Aβ) plaques. There are compelling data suggesting that Aβ aggregation is catalysed by reaction with the metals zinc and copper. METHODOLOGY/PRINCIPAL FINDINGS: We now report that the major human-e...

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Bibliografiske detaljer
Main Authors: Chung, Roger S., Howells, Claire, Eaton, Emma D., Shabala, Lana, Zovo, Kairit, Palumaa, Peep, Sillard, Rannar, Woodhouse, Adele, Bennett, William R., Ray, Shannon, Vickers, James C., West, Adrian K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920313/
https://ncbi.nlm.nih.gov/pubmed/20711450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012030
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