Circulating insulin: the proinsulin-like properties of “big” insulin in patients without islet cell tumors

When plasma is filtered on Sephadex G-50, insulin immunoreactivity is recovered in two peaks. “Big” insulin, the higher molecular weight component, and “little” insulin, the lower molecular weight component, have elution volumes that correspond to those of proinsulin-(125)I and insulin-(125)I respec...

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Pubblicato in:	J Clin Invest
Autori principali:	Sherman, Barry M., Gorden, Phillip, Roth, Jesse, Freychet, Pierre
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1971
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291999/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4323127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI106556
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