Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice

Increasing the expression of Hsp70 (heat-shock protein 70) can inhibit sensory neuron degeneration after axotomy. Since the onset of DPN (diabetic peripheral neuropathy) is associated with the gradual decline of sensory neuron function, we evaluated whether increasing Hsp70 was sufficient to improve...

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Detalhes bibliográficos
Main Authors: Urban, Michael J, Li, Chengyuan, Yu, Cuijuan, Lu, Yuanming, Krise, Joanna M, McIntosh, Michelle P, Rajewski, Roger A, Blagg, Brian S J, Dobrowsky, Rick T
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Neurochemistry 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919983/
https://ncbi.nlm.nih.gov/pubmed/20711301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100015
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