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Structural and dynamic determinants of ligand binding and regulation of Cyclin-dependent Kinase 5 by pathological activator p25 and inhibitory peptide CIP
The crystal structure of the cdk5/p25 complex has provided information on possible molecular mechanisms of ligand binding, specificity, and regulation of the kinase. Comparative molecular dynamics simulations are reported here for physiological conditions. This study provides new insight on the mech...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919306/ https://ncbi.nlm.nih.gov/pubmed/20599546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.040 |
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