Systematic Analysis of Essential Genes Reveals New Regulators of G protein Signaling

The yeast pheromone pathway consists of a canonical heterotrimeric G protein and MAP kinase cascade. To identify new signaling components we systematically evaluated 870 essential genes using a library of repressible-promoter strains. Quantitative transcription-reporter and MAPK activity assays were...

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Bibliographic Details
Main Authors: Cappell, Steven D., Baker, Rachael, Skowyra, Dorota, Dohlman, Henrik G.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919228/
https://ncbi.nlm.nih.gov/pubmed/20542006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.026
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