Protein kinase R contributes to IFN-α/β production during viral infection by regulating IFN mRNA integrity

Cytosolic recognition of viral RNA by the RNA helicases RIG-I and MDA5 is thought to be the major pathway for IFN-α/β induction by RNA viruses. However, other cytoplasmic RNA sensors have historically been implicated in IFN-α/β production. Here we have re-examined the role of the double-stranded RNA...

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Библиографические подробности
Главные авторы: Schulz, Oliver, Pichlmair, Andreas, Rehwinkel, Jan, Rogers, Neil C., Scheuner, Donalyn, Kato, Hiroki, Takeuchi, Osamu, Akira, Shizuo, Kaufman, Randal J., Sousa, Caetano Reis e
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919169/
https://ncbi.nlm.nih.gov/pubmed/20478537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.04.007
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