Identification of a Coiled Coil in Werner Syndrome Protein That Facilitates Multimerization and Promotes Exonuclease Processivity

Werner syndrome (WS) is a rare progeroid disorder characterized by genomic instability, increased cancer incidence, and early onset of a variety of aging pathologies. WS is unique among early aging syndromes in that affected individuals are developmentally normal, and phenotypic onset is in early ad...

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Auteurs principaux: Perry, J. Jefferson P., Asaithamby, Aroumougame, Barnebey, Adam, Kiamanesch, Foad, Chen, David J., Han, Seungil, Tainer, John A., Yannone, Steven M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919133/
https://ncbi.nlm.nih.gov/pubmed/20516064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.124941
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