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Effects of sequence on repeat expansion during DNA replication

Small DNA repeat tracts are located throughout the human genome. The tracts are unstable, and expansions of certain repeat sequences cause neuromuscular disease. DNA expansions appear to be associated with lagging-strand DNA synthesis and DNA repair. At some sites of repeat expansion, e.g. the myoto...

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Bibliographic Details
Main Authors: Heidenfelder, Brooke L., Topal, Michael D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC291863/
https://ncbi.nlm.nih.gov/pubmed/14654691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg920
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