Substitutions at tyrosine 66 of Escherichia coli uracil DNA glycosylase lead to characterization of an efficient enzyme that is recalcitrant to product inhibition

Uracil DNA glycosylase (UDG), a ubiquitous and highly specific enzyme, commences the uracil excision repair pathway. Structural studies have shown that the tyrosine in a highly conserved GQDPY water-activating loop of UDGs blocks the entry of thymine or purines into the active site pocket. To furthe...

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Main Authors: Acharya, Narottam, Talawar, Ramappa K., Saikrishnan, K., Vijayan, M., Varshney, Umesh
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC291862/
https://ncbi.nlm.nih.gov/pubmed/14654697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg918
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